ESPE Yearbook of Paediatric Endocrinology

To read the full abstract: J Clin Med. 2020 Feb 19;9(2). pii: E562. e_rochette@chu-clermontferrand.frThis 5-month prospective case-control study was designed to evaluate the impairment of metabolic response to exercise in 20 childhood acute leukaemia survivors (CALSs), by the analysis of substrate oxidation during submaximal exercise, in comparison with 20 matched healthy controls.<p cla...

To read the full abstract: Pediatrics 144, number 4, October 2019:e20182984Diagnostic delays in the pediatric emergency department (ED) can lead to unnecessary interventions, prolonged length of hospital and emergency department stay (LOS) and even death. This is especially true in diabetic patients presenting with possible diabetic ketoacidosis (DKA). At one institution, DKA determination time (from arrival to diagnosis) was 86 minutes, and 61%...

Abstract: FASEB J. 2019;33:4962–4974.In brief: Glucocorticoid-induced growth impairment is reverted by the mitochondrial peptide humanin in dexamethasone-treated mice without attenuation of anti-inflammatory effects.Comment: Humanin (HN) is a 24 aminoacid peptide that was originally discovered as a neuroprotective factor and later shown ...

J Clin Endocrinol Metab. 2019 Feb 1;104(2):390–396.doi: 10.1210/jc.2018-01105. PubMed PMID: 30247609.Polymorphisms in sex hormone genes have been described in gender dysphoric individuals with inconsistent findings. In this case-control study of 380 trans women and 344 control males, functional variants in 12 sex hormone signaling genes were studied. Significant a...

To read the full abstract: J Clin Endocrinol Metab. 2019; 104(1): 118–126.Primary adrenal insufficiency (AI) is a major clinical manifestation in boys and men with X-linked adrenoleukodystrophy (ALD), a progressive neurodegenerative inborn error of metabolism readily diagnosed by detecting elevated plasma very-long-chain fatty acids (VLCFAs), in particular the ratios of C26:0/...

Lancet Diabetes Endocrinol 2019; 7: 231–40. DOI: 10.1016/S2213-587(19)30026-9• This study uses quantitative data from reputable global data sets to demonstrate that the epidemiology of obesity can be framed as a conceptual model of obesity transition.• A new framework to classify the obesity epidemic is proposed that may assist policy makers and r...

To read the full abstract: Sex Dev. 2017;11(5-6):269-274[Comments on 6.11, 6.12 and 6.13] Evidence for factors necessary for female sexual development are presented in the above 3 publications. Studies of 46,XX DSD individuals show compiling evidence for factors necessary for female development and to counteract...

To read the full abstract: Diabetes Care. 2017;40:849-855Coping strategies for people with chronic diseases include working on risk factors as well as using and employing resilience factors in daily coping strategies. Both strengthes and difficulties may be experienced by people with T1DM. In this study, strengths were strongly related to key resilient outcomes, even in the presence of well-documente...

To read the full abstract: Cell Metab. 2018, 27, 226-236Upon sustained cold exposure, white adipose tissue (WAT) can undergo substantial remodeling, characterized by the appearance of thermogenic brown-like or beige adipocytes. This “browning” of white fat depot also happens in humans and is associated with anti-obesity and anti-diabetic effects. This is why WAT “browning&#...

To read the full abstract: Int Health 2018; 10(2):100-107This article addresses the important issue of acceptance of the congenital screening for congenital hypothyroidism (CH) by the population in general and the families in particular. While it is usually obvious for the health professional that screening for CH is beneficial to the potentially affected neonate, culture, level of education, ...